The present JSS Hospital in MG Road has a long history. In order to serve the needy and poor sections of the society and to bring quality medical service within the reach of the poor, His Holiness Dr. Sri Shivarathri Rajendra Mahaswamiji started J.S.S. Health Centre as early as in the year 1963 on a small scale, under the aegis of JSS Medical Service Trust. Thus the seed of the present Hospital was planted. It is currently an 1800-bed hospital with 35 specialities and super specialities. It is now serving as a teaching hospital to the JSS Medical College.

JSS Hospital is one of the pioneers in offering comprehensive medical services in Mysuru. A notable feature of this hospital is that it caters to the needs of the patients of rural parts of the districts viz., Mysuru, Chamarajanagar, Mandya, Coorg and Hassan in Karnataka and Nilgiris in Tamil Nadu. It treats on average, 800 to 1000 patients daily in the outpatient department and has facilities to accommodate 1800 inpatients. Several health activities are organized in rural areas to create health awareness.